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nk 252 and (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid

nk 252 has been researched along with (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid in 2 studies

Compound Research Comparison

Studies
(nk 252)
Trials
(nk 252)
Recent Studies (post-2010)
(nk 252)
Studies
((1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid)
Trials
((1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid)
Recent Studies (post-2010) ((1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid)
110813013

Protein Interaction Comparison

ProteinTaxonomynk 252 (IC50)(1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid (IC50)
Kelch-like ECH-associated protein 1Homo sapiens (human)1.798
Nuclear factor erythroid 2-related factor 2Homo sapiens (human)2.65

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bach, A; Pallesen, JS; Tran, KT1
Aguayo-Orozco, A; Bach, A; Baig, A; Carmona, RMC; Garcia, AD; Narayanan, D; Pallesen, JS; Solbak, SMØ; Tran, KT; Zang, J1

Other Studies

2 other study(ies) available for nk 252 and (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid

ArticleYear
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.
    Journal of medicinal chemistry, 2018, 09-27, Volume: 61, Issue:18

    Topics: Central Nervous System Diseases; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Structure; NF-E2-Related Factor 2; Protein Interaction Domains and Motifs; Small Molecule Libraries

2018
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
    Journal of medicinal chemistry, 2019, 09-12, Volume: 62, Issue:17

    Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Kelch-Like ECH-Associated Protein 1; Models, Molecular; Molecular Structure; NF-E2-Related Factor 2; Protein Binding; Small Molecule Libraries; Structure-Activity Relationship; Surface Plasmon Resonance

2019