Page last updated: 2024-09-03

nk 252 and (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid

nk 252 has been researched along with (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid in 2 studies

Compound Research Comparison

Studies (nk 252)	Trials (nk 252)	Recent Studies (post-2010) (nk 252)	Studies ((1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid)	Trials ((1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid)	Recent Studies (post-2010) ((1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid)
11	0	8	13	0	13

Protein Interaction Comparison

Protein	Taxonomy	nk 252 (IC50)	(1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid (IC50)
Kelch-like ECH-associated protein 1	Homo sapiens (human)		1.798
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)		2.65

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bach, A; Pallesen, JS; Tran, KT	1
Aguayo-Orozco, A; Bach, A; Baig, A; Carmona, RMC; Garcia, AD; Narayanan, D; Pallesen, JS; Solbak, SMØ; Tran, KT; Zang, J	1

Other Studies

2 other study(ies) available for nk 252 and (1S,2R)-2-[[(1S)-1-[(1,3-dioxo-2-isoindolyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]-oxomethyl]-1-cyclohexanecarboxylic acid

Article	Year
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases. Journal of medicinal chemistry, 2018, 09-27, Volume: 61, Issue:18 Topics: Central Nervous System Diseases; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Structure; NF-E2-Related Factor 2; Protein Interaction Domains and Motifs; Small Molecule Libraries	2018
A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity. Journal of medicinal chemistry, 2019, 09-12, Volume: 62, Issue:17 Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Kelch-Like ECH-Associated Protein 1; Models, Molecular; Molecular Structure; NF-E2-Related Factor 2; Protein Binding; Small Molecule Libraries; Structure-Activity Relationship; Surface Plasmon Resonance	2019

Article

Year

Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases.

Journal of medicinal chemistry, 2018, 09-27, Volume: 61, Issue:18

Topics: Central Nervous System Diseases; Humans; Kelch-Like ECH-Associated Protein 1; Molecular Structure; NF-E2-Related Factor 2; Protein Interaction Domains and Motifs; Small Molecule Libraries

2018

A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.

Journal of medicinal chemistry, 2019, 09-12, Volume: 62, Issue:17

Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Kelch-Like ECH-Associated Protein 1; Models, Molecular; Molecular Structure; NF-E2-Related Factor 2; Protein Binding; Small Molecule Libraries; Structure-Activity Relationship; Surface Plasmon Resonance

2019